Our Science

The Difference

Bio.me’s system of gut health products use simple, science-backed ingredients that are clinically proven to support everyday digestive wellness.

Expert-approved & Science-backed

We look to research, clinical trials and expert approval to support the ingredients we use and the claims we make.

Gut-first Ingredients

We’re mindful of the ingredients we source to ensure we’re healing the microbiome, not harming it.

Simple & Effective

We create products that fit seamlessly into your day-to-day life without sacrificing quality. Clean, efficacious ingredients are our standard, and the foundation for every formula.

Why Fiber?

Importance of Fiber

Fiber provides a wide range of benefits from gut health and microbiome nourishment to weight management and blood sugar control. There are a number of ways to get adequate amounts of fiber into your diet - fruits, vegetables, nuts, seeds - yet the majority of us still face deficiencies. In a recent survey conducted by NHANES (National Health and Nutrition Examination Survey), it was reported that nearly 95% of Americans are deficient in their daily intake of dietary fiber.¹ According to the Institute of Medicine, you should be getting 19-38g of fiber in your diet daily (depending on gender and age).² Most Americans are getting only half of the recommended intake.³ Adding fiber supplements to our diet daily in addition to eating fiber-rich foods is key to supporting digestive wellness and overall health.

Fiber Deficiency

According to a recent survey conducted by NHANES, nearly 95% of Americans are deficient in their daily intake of dietary fiber. According to the Institute of Medicine, you should be getting 19-38g of fiber in your diet daily (depending on gender and age).² Most Americans are getting only half of the recommended intake.¹

Soluble vs Insoluble Fiber

There are many sources of fiber, but the two forms in which we consume fiber are either soluble or insoluble. Soluble fiber dissolves completely in liquid and can provide a number of benefits ranging from microbiome balance to blood sugar control (depending on the fiber source). Unlike soluble fiber, insoluble fiber does not dissolve in liquids, but is important to helping sweep out the digestive tract, promoting regularity and helping alleviate constipation.³

Prebiotic Fiber

It’s important to know that while all prebiotics are fiber, not all fiber is considered a prebiotic. Prebiotic fiber is especially important to gut health because, in order to be classified a prebiotic, it must pass certain scientific tests. First, it has to scientifically demonstrate that it can resist acidity in the gut and reach the upper GI tract, where it is absorbed. Second, it needs to be able to ferment within the gut microflora. And lastly, it should show stimulation of good gut bacteria production within the GI tract.⁴ Prebiotics are important within the gut ecosystem because they provide nourishment and support for probiotics to thrive, which in turn helps balance and diversify our gut’s microbiota. This balance is important for a variety of reasons - general digestive wellness, immune function, and even mental well-being.⁵

Research

1. Zhang H, Lin Z, Chen J, Gan D, Zhou H, Ma Z, Zeng X, Xue Y, Wang X, Zhan Q, Zeng Q and Xu D (2022) Association Between Dietary Fiber Intake and Heart Failure Among Adults: National Health and Nutrition Examination Survey 2009–2018. Front. Cardiovasc. Med. 9:893436. doi: 10.3389/fcvm.2022.893436

2. Quagliani D, Felt-Gunderson P. Closing America's Fiber Intake Gap: Communication Strategies From a Food and Fiber Summit. Am J Lifestyle Med. 2016 Jul 7;11(1):80-85. doi: 10.1177/1559827615588079. PMID: 30202317; PMCID: PMC6124841.

3.https://www.hsph.harvard.edu/nutritionsource/carbohydrates/fiber/

4. Slavin J. Fiber and prebiotics: mechanisms and health benefits. Nutrients. 2013 Apr 22;5(4):1417-35. doi: 10.3390/nu5041417. PMID: 23609775; PMCID: PMC3705355.

5. Sonnenburg, E. D., & Sonnenburg, J. L. (2014). Starving our microbial self: the deleterious consequences of a diet deficient in microbiota-accessible carbohydrates. Cell metabolism, 20(5), 779-786. doi:10.1016/j.cmet.2014.07.003

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The Ingredients

Prebiotics play a crucial role in maintaining gut health by serving as nourishment for good gut bacteria...

Prebiotics play a crucial role in maintaining gut health by serving as nourishment for good gut bacteria. These non-digestible dietary fibers selectively promote the growth and activity of bacteria like Bifidobacterium and Lactobacillus. Numerous scientific studies, including the groundbreaking research by Roberfroid in 1995, consistently demonstrate how prebiotics modulate the composition and diversity of the gut microbiota.¹

A balanced gut microbiota offers a wide range of health benefits, including improved digestion, enhanced nutrient absorption, strengthened immune function, and decreased risk of chronic diseases like obesity, diabetes, and inflammatory bowel disease.² Prebiotics are also important for stimulating the production of short-chain fatty acids (SCFAs), such as butyrate, which are known for their anti-inflammatory properties and ability to reinforce the gut barrier.³

Our science-backed prebiotics:

Psyllium Husk: A soluble and insoluble fiber that moves through the digestive tract sweeping out bad bacteria and toxins to promote better nutrient absorption and overall digestive wellness. Psyllium Husk is an excellent source of fiber that helps mitigate fiber deficiency without causing gas, bloating or GI discomfort.
PHGG (partially hydrolyzed guar gum): An all-natural, completely soluble fiber that comes from guar beans. Unlike many forms of fiber, PHGG is partially hydrolyzed, allowing for ease of use when mixing into liquid and ease of digestion - which helps mitigate bloating, cramping and gas.
Solnul™ (resistant potato starch): A prebiotic resistant starch (R2) that supports microbiome balance, digestion and overall gut health. This clinically studied ingredient has been proven to increase the microbiome's production of Bifidobacterium, an important probiotic for digestive wellness, and significantly increase Akkermansia muciniphila, an important bacteria for improving gut/barrier function and permeability of the gut lining, or leaky gut.
Pomma+® (pomegranate polyphenols): An extract derived from pomegranates that act as a prebiotic in the gut, supporting the growth of short-chain fatty acids and good bacteria while improving gut imbalances caused by bad bacteria overgrowth.

1. Roberfroid, M. B. (1995). Dietary fiber, inulin, and oligofructose: a review comparing their physiological effects. Critical Reviews in Food Science and Nutrition, 35(6), 525-552.

2. Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., ... & Reid, G. (2017). Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nature Reviews Gastroenterology & Hepatology, 14(8), 491-502.

3. Ríos-Covián, D., Ruas-Madiedo, P., Margolles, A., Gueimonde, M., de Los Reyes-Gavilán, C. G., & Salazar, N. (2016). Intestinal short chain fatty acids and their link with diet and human health. Frontiers in Microbiology, 7, 185.